Methylome and transcriptome profiling of giant cell arteritis monocytes reveals novel pathways involved in disease pathogenesis and molecular response to glucocorticoids

OBJECTIVES: Giant cell arteritis (GCA) is a complex systemic vasculitis mediated by the interplay between both genetic and epigenetic factors. Monocytes are crucial players of the inflammation occurring in GCA. Therefore, characterisation of the monocyte methylome and transcriptome in GCA would be h...

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Detalles Bibliográficos
Autores principales: Estupiñán-Moreno, Elkyn, Ortiz-Fernández, Lourdes, Li, Tianlu, Hernández-Rodríguez, Jose, Ciudad, Laura, Andrés-León, Eduardo, Terron-Camero, Laura Carmen, Prieto-González, Sergio, Espígol-Frigolé, Georgina, Cid, Maria Cinta, Márquez, Ana, Ballestar, Esteban, Martín, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Vasculitis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380516/
https://www.ncbi.nlm.nih.gov/pubmed/35705375
http://dx.doi.org/10.1136/annrheumdis-2022-222156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380516/
https://www.ncbi.nlm.nih.gov/pubmed/35705375
http://dx.doi.org/10.1136/annrheumdis-2022-222156

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