Positive Allosteric Modulation of α5-GABA(A) Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle

BACKGROUND: Up to 64% of patients diagnosed with posttraumatic stress disorder (PTSD) experience psychosis, likely attributable to aberrant dopamine neuron activity. We have previously demonstrated that positive allosteric modulators of α5-GABA(A)Rs can selectively decrease hippocampal activity and...

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Detalles Bibliográficos
Autores principales: McCoy, Alexandra M, Prevot, Thomas D, Mian, Md Yenus, Cook, James M, Frazer, Alan, Sibille, Etienne L, Carreno, Flavia R, Lodge, Daniel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Regular Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380714/
https://www.ncbi.nlm.nih.gov/pubmed/35732272
http://dx.doi.org/10.1093/ijnp/pyac035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380714/
https://www.ncbi.nlm.nih.gov/pubmed/35732272
http://dx.doi.org/10.1093/ijnp/pyac035

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