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Positive Allosteric Modulation of α5-GABA(A) Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle

BACKGROUND: Up to 64% of patients diagnosed with posttraumatic stress disorder (PTSD) experience psychosis, likely attributable to aberrant dopamine neuron activity. We have previously demonstrated that positive allosteric modulators of α5-GABA(A)Rs can selectively decrease hippocampal activity and...

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Detalles Bibliográficos
Autores principales:	McCoy, Alexandra M, Prevot, Thomas D, Mian, Md Yenus, Cook, James M, Frazer, Alan, Sibille, Etienne L, Carreno, Flavia R, Lodge, Daniel J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Regular Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380714/ https://www.ncbi.nlm.nih.gov/pubmed/35732272 http://dx.doi.org/10.1093/ijnp/pyac035

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