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A single natural RNA modification can destabilize a U•A-T-rich RNA•DNA-DNA triple helix
Recent studies suggest noncoding RNAs interact with genomic DNA, forming RNA•DNA-DNA triple helices, as a mechanism to regulate transcription. One way cells could regulate the formation of these triple helices is through RNA modifications. With over 140 naturally occurring RNA modifications, we hypo...
Autores principales: | Kunkler, Charlotte N., Schiefelbein, Grace E., O'Leary, Nathan J., McCown, Phillip J., Brown, Jessica A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380742/ https://www.ncbi.nlm.nih.gov/pubmed/35820700 http://dx.doi.org/10.1261/rna.079244.122 |
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