Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy

BACKGROUND: Neuronopathic Gaucher disease (nGD) is a rare neurodegenerative disorder caused by biallelic mutations in GBA and buildup of glycosphingolipids in lysosomes. Neuronal injury and cell death are prominent pathological features; however, the role of GBA in individual cell types and involvem...

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Detalles Bibliográficos
Autores principales: Boddupalli, Chandra Sekhar, Nair, Shiny, Belinsky, Glenn, Gans, Joseph, Teeple, Erin, Nguyen, Tri-Hung, Mehta, Sameet, Guo, Lilu, Kramer, Martin L, Ruan, Jiapeng, Wang, Honggge, Davison, Matthew, Kumar, Dinesh, Vidyadhara, DJ, Zhang, Bailin, Klinger, Katherine, Mistry, Pramod K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381039/
https://www.ncbi.nlm.nih.gov/pubmed/35972072
http://dx.doi.org/10.7554/eLife.79830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381039/
https://www.ncbi.nlm.nih.gov/pubmed/35972072
http://dx.doi.org/10.7554/eLife.79830

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