Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression

Prostate cancer is the second most common cause of cancer mortality in men worldwide. Applying a novel genetically engineered mouse model (GEMM) of aggressive prostate cancer driven by deficiency of the tumor suppressors PTEN and Sprouty2 (SPRY2), we identified enhanced creatine metabolism as a cent...

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Detalles Bibliográficos
Autores principales: Patel, Rachana, Ford, Catriona A., Rodgers, Lisa, Rushworth, Linda K., Fleming, Janis, Mui, Ernest, Zhang, Tong, Watson, David, Lynch, Victoria, Mackay, Gillian, Sumpton, David, Sansom, Owen J., Vande Voorde, Johan, Leung, Hing Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Metabolism and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381098/
https://www.ncbi.nlm.nih.gov/pubmed/35675421
http://dx.doi.org/10.1158/0008-5472.CAN-21-1301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381098/
https://www.ncbi.nlm.nih.gov/pubmed/35675421
http://dx.doi.org/10.1158/0008-5472.CAN-21-1301

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