Cargando…

Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression

Prostate cancer is the second most common cause of cancer mortality in men worldwide. Applying a novel genetically engineered mouse model (GEMM) of aggressive prostate cancer driven by deficiency of the tumor suppressors PTEN and Sprouty2 (SPRY2), we identified enhanced creatine metabolism as a cent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Rachana, Ford, Catriona A., Rodgers, Lisa, Rushworth, Linda K., Fleming, Janis, Mui, Ernest, Zhang, Tong, Watson, David, Lynch, Victoria, Mackay, Gillian, Sumpton, David, Sansom, Owen J., Vande Voorde, Johan, Leung, Hing Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Metabolism and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381098/ https://www.ncbi.nlm.nih.gov/pubmed/35675421 http://dx.doi.org/10.1158/0008-5472.CAN-21-1301

Ejemplares similares

Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts
por: Gorshkov, Kirill, et al.
Publicado: (2019)

Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency
por: Cacciante, Francesco, et al.
Publicado: (2020)

PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer
por: Galbraith, Laura C. A., et al.
Publicado: (2021)

Creatine and cyclocreatine treatment of human colon adenocarcinoma xenografts: (31)P and (1)H magnetic resonance spectroscopic studies
por: Kristensen, C A, et al.
Publicado: (1999)

Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1
por: Patel, Rachana, et al.
Publicado: (2018)

Phase II proof‐of‐concept study of atorvastatin in castration‐resistant prostate cancer
por: Rushworth, Linda K., et al.
Publicado: (2022)

Improving the metabolic fidelity of cancer models with a physiological cell culture medium
por: Vande Voorde, Johan, et al.
Publicado: (2019)

Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure
por: Elgebaly, Salwa A., et al.
Publicado: (2021)

Impedimetric Sensors for Cyclocreatine Phosphate Determination in Plasma Based on Electropolymerized Poly(o-phenylenediamine) Molecularly Imprinted Polymers
por: Abo-Elmagd, Ibrahim F., et al.
Publicado: (2021)

2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
por: Blomme, Arnaud, et al.
Publicado: (2020)

SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis
por: Gao, Meiling, et al.
Publicado: (2012)

From broiler breeder hen feed to the egg and embryo: The molecular effects of guanidinoacetate supplementation on creatine transport and synthesis
por: Reicher, Naama, et al.
Publicado: (2020)

Guanidinoacetic acid supplementation improves feed conversion in broilers subjected to heat stress associated with muscle creatine loading and arginine sparing
por: Majdeddin, M., et al.
Publicado: (2020)

Alkylated epidermal creatine kinase as a biomarker for sulfur mustard exposure: comparison to adducts of albumin and DNA in an in vivo rat study
por: Steinritz, Dirk, et al.
Publicado: (2021)

Creatine nitrate supplementation strengthens energy status and delays glycolysis of broiler muscle via inhibition of LKB1/AMPK pathway
por: Duan, B.B., et al.
Publicado: (2021)

Research Note: Creatine monohydrate alleviates protein breakdown induced by corticosterone via inhibiting ubiquitin proteasome pathway in chicken myotubes
por: Sun, Mingfa, et al.
Publicado: (2022)

HIF-Dependent CKB Expression Promotes Breast Cancer Metastasis, Whereas Cyclocreatine Therapy Impairs Cellular Invasion and Improves Chemotherapy Efficacy
por: Krutilina, Raisa I., et al.
Publicado: (2021)

Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-Inflammatory Drug That Resuscitates Poorly Functioning Hearts and Protects against Development of Heart Failure
por: Elgebaly, Salwa A., et al.
Publicado: (2023)

Oncogenic HSP90 Facilitates Metabolic Alterations in Aggressive B-cell Lymphomas
por: Calvo-Vidal, M. Nieves, et al.
Publicado: (2021)

Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy
por: Fernandez, Mario R., et al.
Publicado: (2022)

Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma
por: Devin, Julie, et al.
Publicado: (2022)

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
por: Davidson, Shawn M., et al.
Publicado: (2022)

Disrupting Circadian Rhythm via the PER1–HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer
por: Wang, Jiao, et al.
Publicado: (2022)

An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination
por: Sheinboim, Danna, et al.
Publicado: (2022)

Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells
por: El-Kenawi, Asmaa, et al.
Publicado: (2023)

Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy
por: Rajan, Prabhakar, et al.
Publicado: (2014)

THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer
por: Blomme, Arnaud, et al.
Publicado: (2022)

The effects of arginine supplementation through different ratios of arginine:lysine on performance, skin quality and creatine levels of broiler chickens fed diets reduced in protein content
por: Oliveira, Carlos H., et al.
Publicado: (2022)

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity
por: Loveridge, Carolyn J., et al.
Publicado: (2017)

Dipeptidyl Peptidase-4 Inhibition Ameliorates Western Diet–Induced Hepatic Steatosis and Insulin Resistance Through Hepatic Lipid Remodeling and Modulation of Hepatic Mitochondrial Function
por: Aroor, Annayya R., et al.
Publicado: (2015)

Cdc2-Like Kinase 2 Suppresses Hepatic Fatty Acid Oxidation and Ketogenesis Through Disruption of the PGC-1α and MED1 Complex
por: Tabata, Mitsuhisa, et al.
Publicado: (2014)

Hepatic de novo lipogenesis is suppressed and fat oxidation is increased by omega-3 fatty acids at the expense of glucose metabolism
por: Green, Charlotte J, et al.
Publicado: (2020)

Increased formate overflow is a hallmark of oxidative cancer
por: Meiser, Johannes, et al.
Publicado: (2018)

Nanoscience and technology: a collection of reviews from Nature journals
por: Rodgers, Peter
Publicado: (2010)

The creatine kinase system and pleiotropic effects of creatine
por: Wallimann, Theo, et al.
Publicado: (2011)

18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy
por: Malviya, Gaurav, et al.
Publicado: (2020)

In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer
por: Rushworth, Linda K, et al.
Publicado: (2020)

The effects of creatine monohydrate supplementation on creatine transporter activity and creatine metabolism in resistance trained males
por: Andre, Tom, et al.
Publicado: (2015)

Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes
por: Zoltner, Martin, et al.
Publicado: (2020)

Creatine and Creatinine
por: Myers, Victor C.
Publicado: (1932)

Cannot write session to /tmp/vufind_sessions/sess_jvkb3vcr6l891b4mofropbqem8