DNA-PK Inhibitor Peposertib Amplifies Radiation-Induced Inflammatory Micronucleation and Enhances TGFβ/PD-L1 Targeted Cancer Immunotherapy

Radiotherapy is the most widely used cancer treatment and improvements in its efficacy and safety are highly sought-after. Peposertib (also known as M3814), a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor, effectively suppresses the repair of radiation-induced DNA double-stran...

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Detalles Bibliográficos
Autores principales: Carr, Michael I., Chiu, Li-Ya, Guo, Yige, Xu, Chunxiao, Lazorchak, Adam S., Yu, Huakui, Qin, Guozhong, Qi, Jin, Marelli, Bo, Lan, Yan, Sun, Qing, Czauderna, Frank, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Cell Fate Decisions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381110/
https://www.ncbi.nlm.nih.gov/pubmed/34980594
http://dx.doi.org/10.1158/1541-7786.MCR-21-0612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381110/
https://www.ncbi.nlm.nih.gov/pubmed/34980594
http://dx.doi.org/10.1158/1541-7786.MCR-21-0612

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