Cargando…

DNA-PK Inhibitor Peposertib Amplifies Radiation-Induced Inflammatory Micronucleation and Enhances TGFβ/PD-L1 Targeted Cancer Immunotherapy

Radiotherapy is the most widely used cancer treatment and improvements in its efficacy and safety are highly sought-after. Peposertib (also known as M3814), a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor, effectively suppresses the repair of radiation-induced DNA double-stran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carr, Michael I., Chiu, Li-Ya, Guo, Yige, Xu, Chunxiao, Lazorchak, Adam S., Yu, Huakui, Qin, Guozhong, Qi, Jin, Marelli, Bo, Lan, Yan, Sun, Qing, Czauderna, Frank, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Cell Fate Decisions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381110/ https://www.ncbi.nlm.nih.gov/pubmed/34980594 http://dx.doi.org/10.1158/1541-7786.MCR-21-0612

Ejemplares similares

DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia
por: Haines, Eric, et al.
Publicado: (2021)

Modeling Androgen Deprivation Therapy–Induced Prostate Cancer Dormancy and Its Clinical Implications
por: Dong, Xin, et al.
Publicado: (2022)

Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
por: Kim, Minjung, et al.
Publicado: (2022)

Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
por: Mohammed, Sabira, et al.
Publicado: (2023)

DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia
por: Carr, Michael I., et al.
Publicado: (2020)

Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death
por: Chiu, Li-Ya, et al.
Publicado: (2023)

Take the shortcut – direct conversion of somatic cells into induced neural stem cells and their biomedical applications
por: Erharter, Anita, et al.
Publicado: (2019)

Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors
por: Turchick, Audrey, et al.
Publicado: (2023)

A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies
por: Zimmermann, Astrid, et al.
Publicado: (2022)

Crítica de la decisión
por: Sfez, Lucien
Publicado: (1984)

Pre-clinical activity of the oral DNA-PK inhibitor, peposertib (M3814), combined with radiation in xenograft models of cervical cancer
por: Gordhandas, Sushmita B., et al.
Publicado: (2022)

Selective Entrapment of Extrachromosomally Amplified DNA by Nuclear Budding and Micronucleation during S Phase
por: Shimizu, Noriaki, et al.
Publicado: (1998)

Demobilisation or Resurrection in Ireland
Publicado: (1919)

Micronucleated lymphocytes in parents of Down syndrome children
por: Silva-Grecco, R.L., et al.
Publicado: (2012)

Análisis de desiciones en medicina : el modelo operante de la medicina del futuro
por: Olivares Larraguibel, Ladislao
Publicado: (1983)

Control administrativo y sistemas de toma de decisiones /
por: Patz L. Alan
Publicado: (1982)

Out-of-sample validation for structured expert judgment of Asian carp establishment in Lake Erie
por: Cooke, Roger M, et al.
Publicado: (2014)

Contributing to agricultural mix:analysis of the living standard measurement study – Integrated survey on agriculture data set
por: Osabohien, Romanus
Publicado: (2018)

Individual altruistic choice and attitude data from Amazon׳s Mechanical Turk
por: te Velde, Vera L.
Publicado: (2018)

Dataset on statistical analysis of editorial board composition of Hindawi journals indexed in Emerging sources citation index
por: Okagbue, Hilary I., et al.
Publicado: (2018)

Dataset on spatial distribution and location of universities in Nigeria
por: Adeyemi, G.A., et al.
Publicado: (2018)

A data-based study in support of Blackbuck related cases from Haryana
por: Kumar, Vikas, et al.
Publicado: (2018)

Citation analytics: Data exploration and comparative analyses of CiteScores of Open Access and Subscription-Based publications indexed in Scopus (2014–2016)
por: Atayero, Aderemi A., et al.
Publicado: (2018)

Heart rate and sentiment experimental data with common timeline
por: Salamon, Jaromír, et al.
Publicado: (2017)

An exploration of research information security data affecting organizational compliance
por: De Matas, Sweden S., et al.
Publicado: (2018)

Data on expenditure, revenue, and economic growth in Nigeria
por: Lukman, Adewale F., et al.
Publicado: (2018)

Dataset and analysis of editorial board composition of 165 Hindawi journals indexed and abstracted in PubMed based on affiliations
por: Okagbue, Hilary I., et al.
Publicado: (2018)

Exploration of editorial board composition, Citescore and percentiles of Hindawi journals indexed in Scopus
por: Okagbue, Hilary I., et al.
Publicado: (2018)

Statistical analysis of frequencies of opponents׳ eliminations in Royal Rumble wrestling matches, 1988–2018
por: Okagbue, Hilary I., et al.
Publicado: (2018)

A benchmark dataset for the multiple depot vehicle scheduling problem
por: Kulkarni, Sarang, et al.
Publicado: (2018)

Generalised framework for multi-criteria method selection: Rule set database and exemplary decision support system implementation blueprints
por: Wątróbski, Jarosław, et al.
Publicado: (2018)

A dataset of European banks in performance evaluation under uncertainty
por: Alfiero, Simona, et al.
Publicado: (2018)

A dataset of healthcare systems for cross-efficiency evaluation in the presence of flexible measure
por: Abolghasem, Sepideh, et al.
Publicado: (2019)

Datasets on mathematical modeling of multi-product multi-stage production to analyze the relationship between production yield, demand, and costs
por: Talay, Işılay, et al.
Publicado: (2019)

Analysis of dataset on editorial board composition of Dove Medical Press by continent
por: Okagbue, Hilary I., et al.
Publicado: (2018)

Exploration of UK Lotto results classified into two periods
por: Okagbue, Hilary I., et al.
Publicado: (2017)

Nested dynamic network data envelopment analysis models with infinitely many decision making units for portfolio evaluation
por: Chang, Tsung-Sheng, et al.
Publicado: (2021)

Hybrid models as transdisciplinary research enablers
por: Tolk, Andreas, et al.
Publicado: (2021)

Complete bibliographic data, cluster assignments and combined citation network of emergency response operations research extant literature
por: Minas, J.P., et al.
Publicado: (2020)

Dataset for solving a hybrid flexibility strategy on personnel scheduling problem in the retail industry
por: Porto, Andrés Felipe, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_e49dn15dfd8msbtf1bhkvjt914