A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies

Radiotherapy and chemical DNA-damaging agents are among the most widely used classes of cancer therapeutics today. Double-strand breaks (DSB) induced by many of these treatments are lethal to cancer cells if left unrepaired. Ataxia telangiectasia-mutated (ATM) kinase plays a key role in the DNA dama...

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Detalles Bibliográficos
Autores principales: Zimmermann, Astrid, Zenke, Frank T., Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T., Blaukat, Andree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
MCT First Disclosures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381122/
https://www.ncbi.nlm.nih.gov/pubmed/35405736
http://dx.doi.org/10.1158/1535-7163.MCT-21-0934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381122/
https://www.ncbi.nlm.nih.gov/pubmed/35405736
http://dx.doi.org/10.1158/1535-7163.MCT-21-0934

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