Diurnal Expression of PD-1 on Tumor-Associated Macrophages Underlies the Dosing Time-Dependent Antitumor Effects of the PD-1/PD-L1 Inhibitor BMS-1 in B16/BL6 Melanoma-Bearing Mice

Cancer cells have acquired several pathways to escape from host immunity in the tumor microenvironment. Programmed death 1 (PD-1) receptor and its ligand PD-L1 are involved in the key pathway of tumor immune escape, and immune checkpoint therapy targeting PD-1 and PD-L1 has been approved for the tre...

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Detalles Bibliográficos
Autores principales: Tsuruta, Akito, Shiiba, Yuki, Matsunaga, Naoya, Fujimoto, Marina, Yoshida, Yuya, Koyanagi, Satoru, Ohdo, Shigehiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Tumor Microenvironment and Immunobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381128/
https://www.ncbi.nlm.nih.gov/pubmed/35190830
http://dx.doi.org/10.1158/1541-7786.MCR-21-0786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381128/
https://www.ncbi.nlm.nih.gov/pubmed/35190830
http://dx.doi.org/10.1158/1541-7786.MCR-21-0786

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