Melatonin Ameliorates the Progression of Alzheimer's Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity

BACKGROUND: The NLRP3 inflammasome is overactivated in the brains of APP/PS1 transgenic mice and AD patients, and mitophagy has an obvious negative regulatory role on NLRP3 inflammasome activation. The protective effect of melatonin in AD may be related to the regulation of mitophagy and NLRP3 infla...

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Detalles Bibliográficos
Autores principales: Fan, Li, Zhaohong, Xie, Xiangxue, Wang, Yingying, Xu, Xiao, Zhang, Xiaoyan, Zhou, Jieke, Yan, Chao, Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381268/
https://www.ncbi.nlm.nih.gov/pubmed/35983247
http://dx.doi.org/10.1155/2022/8099459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381268/
https://www.ncbi.nlm.nih.gov/pubmed/35983247
http://dx.doi.org/10.1155/2022/8099459

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