Genetic and environmental variation impact transferability of polygenic risk scores

Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk as...

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Detalles Bibliográficos
Autores principales: Araújo, Daniel S., Wheeler, Heather E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381406/
https://www.ncbi.nlm.nih.gov/pubmed/35858592
http://dx.doi.org/10.1016/j.xcrm.2022.100687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381406/
https://www.ncbi.nlm.nih.gov/pubmed/35858592
http://dx.doi.org/10.1016/j.xcrm.2022.100687

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