Genetic and environmental variation impact transferability of polygenic risk scores

Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk as...

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Detalles Bibliográficos
Autores principales: Araújo, Daniel S., Wheeler, Heather E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381406/
https://www.ncbi.nlm.nih.gov/pubmed/35858592
http://dx.doi.org/10.1016/j.xcrm.2022.100687
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author Araújo, Daniel S.
Wheeler, Heather E.
author_facet Araújo, Daniel S.
Wheeler, Heather E.
author_sort Araújo, Daniel S.
collection PubMed
description Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.
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spelling pubmed-93814062022-08-18 Genetic and environmental variation impact transferability of polygenic risk scores Araújo, Daniel S. Wheeler, Heather E. Cell Rep Med Spotlight Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment. Elsevier 2022-07-19 /pmc/articles/PMC9381406/ /pubmed/35858592 http://dx.doi.org/10.1016/j.xcrm.2022.100687 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Spotlight
Araújo, Daniel S.
Wheeler, Heather E.
Genetic and environmental variation impact transferability of polygenic risk scores
title Genetic and environmental variation impact transferability of polygenic risk scores
title_full Genetic and environmental variation impact transferability of polygenic risk scores
title_fullStr Genetic and environmental variation impact transferability of polygenic risk scores
title_full_unstemmed Genetic and environmental variation impact transferability of polygenic risk scores
title_short Genetic and environmental variation impact transferability of polygenic risk scores
title_sort genetic and environmental variation impact transferability of polygenic risk scores
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381406/
https://www.ncbi.nlm.nih.gov/pubmed/35858592
http://dx.doi.org/10.1016/j.xcrm.2022.100687
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