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Genetic and environmental variation impact transferability of polygenic risk scores
Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk as...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381406/ https://www.ncbi.nlm.nih.gov/pubmed/35858592 http://dx.doi.org/10.1016/j.xcrm.2022.100687 |