γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation

We here defined the impacts of γ-secretase inhibitors (GSIs) on T-cell-dependent BCMA-specific multiple myeloma (MM) cell lysis and immunomodulatory effects induced by bispecific antibodies (BisAbs). GSIs-induced membrane BCMA (mBCMA) accumulation reached near maximum within 4 h and sustained over 4...

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Detalles Bibliográficos
Autores principales: Chen, Hailin, Yu, Tengteng, Lin, Liang, Xing, Lijie, Cho, Shih-Feng, Wen, Kenneth, Aardalen, Kimberly, Oka, Adwait, Lam, Joni, Daley, Mike, Lu, Haihui, Munshi, Nikhil, Anderson, Kenneth C., Tai, Yu-Tzu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381512/
https://www.ncbi.nlm.nih.gov/pubmed/35973981
http://dx.doi.org/10.1038/s41408-022-00716-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381512/
https://www.ncbi.nlm.nih.gov/pubmed/35973981
http://dx.doi.org/10.1038/s41408-022-00716-3

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