Cargando…

Gene-expression profiles of pretreatment biopsies predict complete response of rectal cancer patients to preoperative chemoradiotherapy

PURPOSE: Preoperative (neoadjuvant) chemoradiotherapy (CRT) and total mesorectal excision is the standard treatment for rectal cancer patients (UICC stage II/III). Up to one-third of patients treated with CRT achieve a pathological complete response (pCR). These patients could be spared from surgery...

Descripción completa

Detalles Bibliográficos
Autores principales:	Emons, Georg, Auslander, Noam, Jo, Peter, Kitz, Julia, Azizian, Azadeh, Hu, Yue, Hess, Clemens F., Roedel, Claus, Sax, Ulrich, Salinas, Gabriela, Stroebel, Philipp, Kramer, Frank, Beissbarth, Tim, Grade, Marian, Ghadimi, Michael, Ruppin, Eytan, Ried, Thomas, Gaedcke, Jochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381580/ https://www.ncbi.nlm.nih.gov/pubmed/35597871 http://dx.doi.org/10.1038/s41416-022-01842-2

Ejemplares similares

Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy
por: Jo, Peter, et al.
Publicado: (2017)

Prognostic Value of MicroRNAs in Preoperative Treated Rectal Cancer
por: Azizian, Azadeh, et al.
Publicado: (2016)

Heterogeneity of KRAS Mutation Status in Rectal Cancer
por: Jo, Peter, et al.
Publicado: (2016)

KRAS mutation status concordance between the primary tumor and the corresponding metastasis in patients with rectal cancer
por: Jo, Peter, et al.
Publicado: (2020)

Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies
por: Jo, Peter, et al.
Publicado: (2016)

Impact of Portal Vein Resection (PVR) in Patients Who Underwent Curative Intended Pancreatic Head Resection
por: Bernhardt, Markus, et al.
Publicado: (2023)

Impact of RNA degradation on gene expression profiling
por: Opitz, Lennart, et al.
Publicado: (2010)

Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer
por: Flebbe, Hannah, et al.
Publicado: (2019)

The molecular basis of chemoradiosensitivity in rectal cancer:implications for personalized therapies
por: Grade, Marian, et al.
Publicado: (2012)

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer
por: Gaedcke, Jochen, et al.
Publicado: (2014)

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies
por: Patkar, Sushant, et al.
Publicado: (2021)

Data-Driven Metabolic Pathway Compositions Enhance Cancer Survival Prediction
por: Auslander, Noam, et al.
Publicado: (2016)

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy
por: Koerdel, Kristin, et al.
Publicado: (2021)

Targeting STAT3 Signaling Facilitates Responsiveness of Pancreatic Cancer Cells to Chemoradiotherapy
por: Flebbe, Hannah, et al.
Publicado: (2022)

Inhibition of Wnt/β-Catenin Signaling Sensitizes Esophageal Cancer Cells to Chemoradiotherapy
por: Spitzner, Melanie, et al.
Publicado: (2021)

UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib
por: Landmann, H, et al.
Publicado: (2014)

Surgical treatment of metastatic VIPoma: a case report
por: Azizian, Azadeh, et al.
Publicado: (2021)

Preoperative Chemoradiotherapy Does Not Necessarily Reduce Lymph Node Retrieval in Rectal Cancer Specimens—Results from a Prospective Evaluation with Extensive Pathological Work-up
por: Sprenger, Thilo, et al.
Publicado: (2009)

STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy
por: Spitzner, Melanie, et al.
Publicado: (2014)

A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells
por: Wolff, Alexander, et al.
Publicado: (2018)

Pretreatment CT and PET radiomics predicting rectal cancer patients in response to neoadjuvant chemoradiotherapy
por: Yuan, Zhigang, et al.
Publicado: (2021)

Correction: A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells
por: Wolff, Alexander, et al.
Publicado: (2019)

CA19-9 for detecting recurrence of pancreatic cancer
por: Azizian, Azadeh, et al.
Publicado: (2020)

A joint analysis of transcriptomic and metabolomic data uncovers enhanced enzyme-metabolite coupling in breast cancer
por: Auslander, Noam, et al.
Publicado: (2016)

The mesopancreas is the primary site for R1 resection in pancreatic head cancer: relevance for clinical trials
por: Gaedcke, J., et al.
Publicado: (2009)

Treatment options of metastatic and nonmetastatic VIPoma: a review
por: Azizian, Azadeh, et al.
Publicado: (2022)

Incidence, Associated Risk Factors, and Outcomes of Postoperative Arrhythmia After Upper Gastrointestinal Surgery
por: Rühlmann, Felix, et al.
Publicado: (2022)

Cure Is Possible: Extensively Metastatic HER2-Positive Gastric Carcinoma with 5 years of Complete Remission after Therapy with the FLOT Regimen and Trastuzumab
por: Schade, Sebastian, et al.
Publicado: (2022)

Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact
por: Grade, Marian, et al.
Publicado: (2006)

Negative impact of pretreatment anemia on local control after neoadjuvant chemoradiotherapy and surgery for rectal cancer
por: Lee, Hyebin, et al.
Publicado: (2012)

Pretreatment TACC3 expression in locally advanced rectal cancer decreases the response to neoadjuvant chemoradiotherapy
por: Ma, Wen-juan, et al.
Publicado: (2018)

Impact of Mucin Proportion in the Pretreatment MRI on the Outcomes of Rectal Cancer Patients Undergoing Neoadjuvant Chemoradiotherapy
por: Kim, Eunji, et al.
Publicado: (2019)

Pretreatment Microvessel Density for Predicting of Tumor Responsiveness to Neoadjuvant Chemoradiotherapy of Locally Advanced Rectal Cancer
por: Boonya-Ussadorn, Chinakrit, et al.
Publicado: (2023)

Pelvic intraoperative neuromonitoring during robotic-assisted low anterior resection for rectal cancer
por: Grade, Marian, et al.
Publicado: (2015)

Combined targeting of HER-2 and HER-3 represents a promising therapeutic strategy in colorectal cancer
por: Conradi, Lena-Christin, et al.
Publicado: (2019)

Pretreatment Inflammatory-Nutritional Biomarkers Predict Responses to Neoadjuvant Chemoradiotherapy and Survival in Locally Advanced Rectal Cancer
por: Wang, Yijun, et al.
Publicado: (2021)

The GENDULF algorithm: mining transcriptomics to uncover modifier genes for monogenic diseases
por: Auslander, Noam, et al.
Publicado: (2020)

Incidence and impact of new-onset postoperative arrhythmia after surgery of the lower gastrointestinal tract
por: Rühlmann, Felix, et al.
Publicado: (2023)

Treating patients with advanced rectal cancer and lateral pelvic lymph nodes with preoperative chemoradiotherapy based on pretreatment imaging
por: Otowa, Yasunori, et al.
Publicado: (2015)

Prognostic value of pretreatment systemic inflammatory markers in patients with locally advanced rectal cancer following neoadjuvant chemoradiotherapy
por: Zhang, Yiyi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_h0vfcspljqc2jlok8b5vnsra1q