A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B receptor (TrkB) are expressed in human osteoblasts and mediate fracture healing. BDNF/TrkB signaling activates Akt that phosphorylates and inhibits asparagine endopeptidase (AEP), which regulates the differentiation fate o...

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Detalles Bibliográficos
Autores principales: Xiong, Jing, Liao, Jianming, Liu, Xia, Zhang, Zhaohui, Adams, Jonathan, Pacifici, Roberto, Ye, Keqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381595/
https://www.ncbi.nlm.nih.gov/pubmed/35973996
http://dx.doi.org/10.1038/s41467-022-32435-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381595/
https://www.ncbi.nlm.nih.gov/pubmed/35973996
http://dx.doi.org/10.1038/s41467-022-32435-5

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