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A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B receptor (TrkB) are expressed in human osteoblasts and mediate fracture healing. BDNF/TrkB signaling activates Akt that phosphorylates and inhibits asparagine endopeptidase (AEP), which regulates the differentiation fate o...

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Detalles Bibliográficos
Autores principales:	Xiong, Jing, Liao, Jianming, Liu, Xia, Zhang, Zhaohui, Adams, Jonathan, Pacifici, Roberto, Ye, Keqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381595/ https://www.ncbi.nlm.nih.gov/pubmed/35973996 http://dx.doi.org/10.1038/s41467-022-32435-5

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