Cargando…

Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach

Visceral leishmaniasis (VL), caused by Leishmania infantum, is an oft-fatal neglected tropical disease. In the absence of an effective vaccine, the control of leishmaniasis relies exclusively on chemotherapy. Due to the lack of established molecular/genetic markers denoting parasite resistance, clin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ibarra-Meneses, Ana Victoria, Corbeil, Audrey, Wagner, Victoria, Beaudry, Francis, do Monte-Neto, Rubens L., Fernandez-Prada, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381709/ https://www.ncbi.nlm.nih.gov/pubmed/35992178 http://dx.doi.org/10.3389/fcimb.2022.954144

Ejemplares similares

Identification of asymptomatic Leishmania infections: a scoping review
por: Ibarra-Meneses, Ana Victoria, et al.
Publicado: (2022)

Metalloprotease Gp63-Targeting Novel Glycoside Exhibits Potential Antileishmanial Activity
por: Chakrabarti, Amrita, et al.
Publicado: (2022)

Three different mutations in the DNA topoisomerase 1B in Leishmania infantum contribute to resistance to antitumor drug topotecan
por: Rosa-Teijeiro, Chloé, et al.
Publicado: (2021)

Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery
por: Bhattacharya, Arijit, et al.
Publicado: (2020)

Editorial: Direct and Indirect Interactions of HIV With Host Cells
por: Tsukamoto, Tetsuo, et al.
Publicado: (2021)

Editorial: The Pathogenic Yersiniae–Advances in the Understanding of Physiology and Virulence, Second Edition
por: Francis, Matthew S., et al.
Publicado: (2019)

Three types of Leishmania mexicana amastigotes: Proteome comparison by quantitative proteomic analysis
por: Pacakova, Lenka, et al.
Publicado: (2022)

I329L protein-based indirect ELISA for detecting antibodies specific to African swine fever virus
por: Shen, Zhiyong, et al.
Publicado: (2023)

Proteomic analysis reveals changes in the proteome of human THP-1 macrophages infected with Paracoccidioides brasiliensis
por: de Figueiredo, Ana Marina Barroso, et al.
Publicado: (2023)

Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing
por: Martinez-Hernandez, J. Eduardo, et al.
Publicado: (2021)

Proteome Profiling of RNF213 Depleted Cells Reveals Nitric Oxide Regulator DDAH1 Antilisterial Activity
por: Martina, Lia, et al.
Publicado: (2021)

Different regulatory mechanisms of the capsule in hypervirulent Klebsiella pneumonia: “direct” wcaJ variation vs. “indirect” rmpA regulation
por: Wang, Weiwen, et al.
Publicado: (2023)

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
por: Jain, Surendra K., et al.
Publicado: (2012)

Microwaves can kill malaria parasites non-thermally
por: Coronado, Lorena M., et al.
Publicado: (2023)

Proteomic Profile of Procoagulant Extracellular Vesicles Reflects Complement System Activation and Platelet Hyperreactivity of Patients with Severe COVID-19
por: Moraes, Emilly Caroline dos Santos, et al.
Publicado: (2022)

An Alliance of Gel-Based and Gel-Free Proteomic Techniques Displays Substantial Insight Into the Proteome of a Virulent and an Attenuated Histomonas meleagridis Strain
por: Monoyios, Andreas, et al.
Publicado: (2018)

Serial Systemic Candida albicans Infection Highlighted by Proteomics
por: Arita, Glaucia Sayuri, et al.
Publicado: (2019)

Proteomic Analysis and Virulence Assessment of Granulicatella adiacens Secretome
por: Karched, Maribasappa, et al.
Publicado: (2019)

Proteomic Mapping of Multifunctional Complexes Within Triatomine Saliva
por: Santiago, Paula Beatriz, et al.
Publicado: (2020)

Proteome and Microbiome Mapping of Human Gingival Tissue in Health and Disease
por: Bao, Kai, et al.
Publicado: (2020)

Proteomic and Functional Analysis of the Effects of Quinoxaline Derivatives on Entamoeba histolytica
por: Avila-Bonilla, Rodolfo Gamaliel, et al.
Publicado: (2022)

NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?
por: Stary, Victoria, et al.
Publicado: (2020)

Antileishmanial metallodrugs and the elucidation of new drug targets linked to post-translational modifications machinery: pitfalls and progress
por: do Monte, Rubens Lima, et al.
Publicado: (2022)

Editorial: Signaling in stress sensing and resistance in parasitic protozoa
por: Bhattacharya, Arijit, et al.
Publicado: (2022)

Proteomic Analysis of Copper Toxicity in Human Fungal Pathogen Cryptococcus neoformans
por: Sun, Tianshu, et al.
Publicado: (2021)

Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach
por: Montaño, Karen J., et al.
Publicado: (2021)

SARS-CoV-2 Pathogenesis: Imbalance in the Renin-Angiotensin System Favors Lung Fibrosis
por: Delpino, M. Victoria, et al.
Publicado: (2020)

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection
por: Flaherty, Rebecca A., et al.
Publicado: (2018)

Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection
por: Hammers, Daniel E., et al.
Publicado: (2022)

Cellular Markers of Active Disease and Cure in Different Forms of Leishmania infantum-Induced Disease
por: Botana, Laura, et al.
Publicado: (2018)

Targeting Host Glycolysis as a Strategy for Antimalarial Development
por: Jezewski, Andrew J., et al.
Publicado: (2021)

Improved Antileishmanial Activity of Dppz through Complexation with Antimony(III) and Bismuth(III): Investigation of the Role of the Metal
por: Lizarazo-Jaimes, Edgar H., et al.
Publicado: (2012)

Immunopathogenesis of Hepatic Brucellosis
por: Giambartolomei, Guillermo Hernán, et al.
Publicado: (2019)

Integration of Transcriptomic and Proteomic Approaches Reveals the Temperature-Dependent Virulence of Pseudomonas plecoglossicida
por: Huang, Lixing, et al.
Publicado: (2018)

Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin
por: Mir, Dilawar Ahmad, et al.
Publicado: (2019)

Sickle Cell Trait Modulates the Proteome and Phosphoproteome of Plasmodium falciparum-Infected Erythrocytes
por: Chauvet, Margaux, et al.
Publicado: (2021)

Proteomic Analyses of Acinetobacter baumannii Clinical Isolates to Identify Drug Resistant Mechanism
por: Wang, Ping, et al.
Publicado: (2021)

Comparative Proteomics Analysis for Elucidating the Interaction Between Host Cells and Toxoplasma gondii
por: Sun, Hui, et al.
Publicado: (2021)

Proteomics Investigations of Potential Protein Biomarkers in Sera of Rabbits Infected With Schistosoma japonicum
por: Bi, Nian-Nian, et al.
Publicado: (2021)

Targeted proteomics links virulence factor expression with clinical severity in staphylococcal pneumonia
por: Pivard, Mariane, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_onfms5g4ruqjenidm8b0naopaq