Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival

SARM1 is a central executioner of programmed axon death, and this role requires intrinsic NAD(P)ase or related enzyme activity. A complete absence of SARM1 robustly blocks axon degeneration in mice, but even a partial depletion confers meaningful protection. Since axon loss contributes substantially...

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Detalles Bibliográficos
Autores principales: Ademi, Mirlinda, Yang, Xiuna, Coleman, Michael P., Gilley, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381744/
https://www.ncbi.nlm.nih.gov/pubmed/35974060
http://dx.doi.org/10.1038/s41598-022-18052-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381744/
https://www.ncbi.nlm.nih.gov/pubmed/35974060
http://dx.doi.org/10.1038/s41598-022-18052-8

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