Cargando…
Natural variants of human SARM1 cause both intrinsic and dominant loss-of-function influencing axon survival
SARM1 is a central executioner of programmed axon death, and this role requires intrinsic NAD(P)ase or related enzyme activity. A complete absence of SARM1 robustly blocks axon degeneration in mice, but even a partial depletion confers meaningful protection. Since axon loss contributes substantially...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381744/ https://www.ncbi.nlm.nih.gov/pubmed/35974060 http://dx.doi.org/10.1038/s41598-022-18052-8 |