ABCA1 is an extracellular phospholipid translocase

Production of high density lipoprotein (HDL) requires ATP-binding cassette transporter A1 (ABCA1) to drive phospholipid (PL) from the plasma membrane into extracellular apolipoprotein A-I. Here, we use simulations to show that domains of ABCA1 within the plasma membrane remove PL from the membrane’s...

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Detalles Bibliográficos
Autores principales: Segrest, Jere P., Tang, Chongren, Song, Hyun D., Jones, Martin K., Davidson, W. Sean, Aller, Stephen G., Heinecke, Jay W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381790/
https://www.ncbi.nlm.nih.gov/pubmed/35974019
http://dx.doi.org/10.1038/s41467-022-32437-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381790/
https://www.ncbi.nlm.nih.gov/pubmed/35974019
http://dx.doi.org/10.1038/s41467-022-32437-3

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