Cargando…

Mapping the dynamics of insulin-responsive pathways in the blood–brain barrier endothelium using time-series transcriptomics data

Critical functions of the blood–brain barrier (BBB), including cerebral blood flow, energy metabolism, and immunomodulation, are regulated by insulin signaling pathways. Therefore, endothelial insulin resistance could lead to BBB dysfunction, which is associated with neurodegenerative diseases such...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zengtao, Tang, Xiaojia, Swaminathan, Suresh K., Kandimalla, Karunya K., Kalari, Krishna R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381797/ https://www.ncbi.nlm.nih.gov/pubmed/35974022 http://dx.doi.org/10.1038/s41540-022-00235-8

Ejemplares similares

BBBomics-Human Blood Brain Barrier Transcriptomics Hub
por: Kalari, Krishna R., et al.
Publicado: (2016)

Delivery of RNA to the Blood-Brain Barrier Endothelium Using Cationic Bicelles
por: Cheng, Joan, et al.
Publicado: (2023)

Pneumococcal Encounter With the Blood–Brain Barrier Endothelium
por: Anil, Anjali, et al.
Publicado: (2020)

Gene expression in the corneal endothelium of Fuchs endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4
por: Wieben, Eric D., et al.
Publicado: (2018)

Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy
por: Wieben, Eric D., et al.
Publicado: (2019)

The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium
por: Schlereth, Katharina, et al.
Publicado: (2018)

Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice
por: Gali, Chaitanya Chakravarthi, et al.
Publicado: (2019)

Design, Synthesis, and Preliminary Evaluation of [(68)Ga]Ga-NOTA-Insulin as a PET Probe in an Alzheimer’s Disease Mouse Model
por: Taubel, Jillissa C., et al.
Publicado: (2022)

Transcriptome-Wide Analysis of UTRs in Non-Small Cell Lung Cancer Reveals Cancer-Related Genes with SNV-Induced Changes on RNA Secondary Structure and miRNA Target Sites
por: Sabarinathan, Radhakrishnan, et al.
Publicado: (2014)

Non-Human Primate Blood–Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model
por: Chaves, Catarina, et al.
Publicado: (2020)

The Drosophila blood-brain barrier: development and function of a glial endothelium
por: Limmer, Stefanie, et al.
Publicado: (2014)

The Vascular Endothelium, a Benign Restrictive Barrier? NO! Role of Nitric Oxide in Regulating Insulin Action
por: Richey, Joyce M.
Publicado: (2013)

Two barriers for sodium in vascular endothelium?
por: Oberleithner, Hans
Publicado: (2012)

Hemodynamic actions of insulin: beyond the endothelium
por: Montero, David
Publicado: (2013)

Mechanism of Neuronal versus Endothelial Cell Uptake of Alzheimer's Disease Amyloid β Protein
por: Kandimalla, Karunya K., et al.
Publicado: (2009)

The Endothelium Abridges Insulin Resistance to Premature Aging
por: Avogaro, Angelo, et al.
Publicado: (2013)

A comprehensive analysis of breast cancer microbiota and host gene expression
por: Thompson, Kevin J., et al.
Publicado: (2017)

The Human Blood-Nerve Barrier Transcriptome
por: Palladino, Steven P., et al.
Publicado: (2017)

A molecular map of murine lymph node blood vascular endothelium at single cell resolution
por: Brulois, Kevin, et al.
Publicado: (2020)

Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line
por: Sajja, Ravi K, et al.
Publicado: (2014)

MORPHOMETRIC DATA ON THE ENDOTHELIUM OF BLOOD CAPILLARIES
por: Simionescu, Maia, et al.
Publicado: (1974)

Vascularized Microfluidics and the Blood–Endothelium Interface
por: Hesh, Christopher A., et al.
Publicado: (2019)

Role of the Endothelium during Tumor Cell Metastasis: Is the Endothelium a Barrier or a Promoter for Cell Invasion and Metastasis?
por: Mierke, Claudia Tanja
Publicado: (2008)

Endocytosis of insulin at the blood-brain barrier
por: Pemberton, Sarah, et al.
Publicado: (2022)

Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium
por: Tran, Huy, et al.
Publicado: (2019)

DDEL-15. NANOTHERAPEUTIC TARGETING OF TUMOR ENDOTHELIUM FOR ENHANCING DRUG DELIVERY PAST THE BLOOD-BRAIN BARRIER
por: Kiguchi, Hiro, et al.
Publicado: (2020)

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium
por: Bonkhofer, Florian, et al.
Publicado: (2019)

Salt overload damages the glycocalyx sodium barrier of vascular endothelium
por: Oberleithner, Hans, et al.
Publicado: (2011)

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo
por: Duncan, Edward R., et al.
Publicado: (2008)

Combination of HIV-1 and Diabetes Enhances Blood Brain Barrier Injury via Effects on Brain Endothelium and Pericytes
por: Rom, Slava, et al.
Publicado: (2020)

CCL4 induces inflammatory signalling and barrier disruption in the neurovascular endothelium
por: Estevao, Carolina, et al.
Publicado: (2021)

The Endothelium Is Both a Target and a Barrier of HDL’s Protective Functions
por: Robert, Jérôme, et al.
Publicado: (2021)

Endothelium-dependent relaxation induced by etomidate in the aortas of insulin-resistant rats
por: Xue, Wenxin, et al.
Publicado: (2018)

HH Domain of Alzheimer’s Disease Aβ Provides Structural Basis for Neuronal Binding in PC12 and Mouse Cortical/Hippocampal Neurons
por: Poduslo, Joseph F., et al.
Publicado: (2010)

Immune function of the blood-brain barrier: incomplete presentation of protein (auto-)antigens by rat brain microvascular endothelium in vitro
Publicado: (1990)

A least-squares-fitting procedure for an efficient preclinical ranking of passive transport across the blood–brain barrier endothelium
por: Jorgensen, Christian, et al.
Publicado: (2023)

BSBM-13 MELANOMA CELLS PRODUCE A SUSPENSION SUB-POPULATION THAT DRASTICALLY DISRUPTS THE BLOOD-BRAIN BARRIER ENDOTHELIUM
por: Anchan, Akshata, et al.
Publicado: (2023)

Frequency of MicroRNA Response Elements Identifies Pathologically Relevant Signaling Pathways in Triple-Negative Breast Cancer
por: Nair, Asha A., et al.
Publicado: (2020)

Comparative transcriptome analysis of inner blood-retinal barrier and blood–brain barrier in rats
por: Li, Y., et al.
Publicado: (2021)

Rapid and Efficient Clearance of Blood-borne Virus by Liver Sinusoidal Endothelium
por: Ganesan, Latha P., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_a44f2n4hqvidd4cgahvs46j37b