Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma

The goal of this study was to test the role cellular senescence plays in the increased inflammation, chronic liver disease, and hepatocellular carcinoma seen in mice null for Cu/Zn‐Superoxide dismutase (Sod1KO). To inhibit senescence, wildtype (WT) and Sod1KO mice were given the senolytics, dasatini...

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Detalles Bibliográficos
Autores principales: Thadathil, Nidheesh, Selvarani, Ramasamy, Mohammed, Sabira, Nicklas, Evan H., Tran, Albert L., Kamal, Maria, Luo, Wenyi, Brown, Jacob L., Lawrence, Marcus M., Borowik, Agnieszka K., Miller, Benjamin F., Van Remmen, Holly, Richardson, Arlan, Deepa, Sathyaseelan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381894/
https://www.ncbi.nlm.nih.gov/pubmed/35869934
http://dx.doi.org/10.1111/acel.13676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381894/
https://www.ncbi.nlm.nih.gov/pubmed/35869934
http://dx.doi.org/10.1111/acel.13676

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