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Machine-learning analysis of intrinsically disordered proteins identifies key factors that contribute to neurodegeneration-related aggregation

Protein structure is determined by the amino acid sequence and a variety of post-translational modifications, and provides the basis for physiological properties. Not all proteins in the proteome attain a stable conformation; roughly one third of human proteins are unstructured or contain intrinsica...

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Detalles Bibliográficos
Autores principales: Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Shmookler Reis, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382113/
https://www.ncbi.nlm.nih.gov/pubmed/35992603
http://dx.doi.org/10.3389/fnagi.2022.938117