Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading

Chronic joint pain is a major healthcare challenge with a staggering socioeconomic burden. Pain from synovial joints is mediated by the innervated collagenous capsular ligament that surrounds the joint and encodes nociceptive signals. The interstitial collagenase MMP-1 is elevated in painful joint p...

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Detalles Bibliográficos
Autores principales: Ita, Meagan E., Singh, Sagar, Troche, Harrison R., Welch, Rachel L., Winkelstein, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382200/
https://www.ncbi.nlm.nih.gov/pubmed/35992346
http://dx.doi.org/10.3389/fbioe.2022.926675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382200/
https://www.ncbi.nlm.nih.gov/pubmed/35992346
http://dx.doi.org/10.3389/fbioe.2022.926675

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