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Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies

Abnormally accumulated tau protein aggregates are one of the hallmarks of neurodegenerative diseases, including Alzheimer’s disease (AD). In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to analyze disease model mice expressing human MAPT(...

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Detalles Bibliográficos
Autores principales: Tsumagari, Kazuya, Sato, Yoshiaki, Shimozawa, Aki, Aoyagi, Hirofumi, Okano, Hideyuki, Kuromitsu, Junro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382322/
https://www.ncbi.nlm.nih.gov/pubmed/35992067
http://dx.doi.org/10.1016/j.isci.2022.104832