Cargando…

Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology

BACKGROUND: Abdominal aortic aneurysm (AAA), characterized by a continued expansion of the aorta, leads to rupture if not surgically repaired. Mice aid the study of disease progression and its underlying mechanisms since sequential studies of aneurysm development are not feasible in humans. The pres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morgan, Stephanie, Lee, Lang Ho, Halu, Arda, Nicolau, Jessica S., Higashi, Hideyuki, Ha, Anna H., Wen, Jennifer R., Daugherty, Alan, Libby, Peter, Cameron, Scott J., Mix, Doran, Aikawa, Elena, Owens, A. Phillip, Singh, Sasha A., Aikawa, Masanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382335/ https://www.ncbi.nlm.nih.gov/pubmed/35990960 http://dx.doi.org/10.3389/fcvm.2022.889994

Ejemplares similares

Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19
por: Jha, Prabhash Kumar, et al.
Publicado: (2021)

Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification
por: Goto, Shinji, et al.
Publicado: (2019)

Elastogenesis Correlates With Pigment Production in Murine Aortic Valve Leaflets
por: Hutcheson, Joshua D., et al.
Publicado: (2021)

Integration of Functional Imaging, Cytometry, and Unbiased Proteomics Reveals New Features of Endothelial-to-Mesenchymal Transition in Ischemic Mitral Valve Regurgitation in Human Patients
por: Lupieri, Adrien, et al.
Publicado: (2021)

Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification
por: Tanaka, Takeshi, et al.
Publicado: (2022)

Annexin A1–dependent tethering promotes extracellular vesicle aggregation revealed with single–extracellular vesicle analysis
por: Rogers, Maximillian A., et al.
Publicado: (2020)

Intermediate pressure-normalized principal wall strain values are associated with increased abdominal aortic aneurysmal growth rates
por: Zottola, Zachary R., et al.
Publicado: (2023)

Connections for Matters of the Heart: Network Medicine in Cardiovascular Diseases
por: Sonawane, Abhijeet Rajendra, et al.
Publicado: (2022)

Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development
por: Yabusaki, Katsumi, et al.
Publicado: (2016)

Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation
por: Halu, Arda, et al.
Publicado: (2018)

The distinct metabolism between large and small HDL indicates unique origins of human apolipoprotein A4
por: Andraski, Allison B., et al.
Publicado: (2023)

Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease
por: Decano, Julius L., et al.
Publicado: (2018)

A Combined Gas-Phase Separation Strategy for ADP-ribosylated Peptides
por: Kasai, Taku, et al.
Publicado: (2023)

The RiboMaP Spectral Annotation Method Applied to Various ADP-Ribosylome Studies Including INF-γ-Stimulated Human Cells and Mouse Tissues
por: Singh, Sasha A., et al.
Publicado: (2022)

In silico Drug Screening Approach Using L1000-Based Connectivity Map and Its Application to COVID-19
por: Asano, Takaharu, et al.
Publicado: (2022)

Lipoprotein(a) Induces Vesicular Cardiovascular Calcification Revealed With Single-Extracellular Vesicle Analysis
por: Rogers, Maximillian A., et al.
Publicado: (2022)

A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation
por: Higashi, Hideyuki, et al.
Publicado: (2019)

Editorial: New Trends in Vascular Inflammation Research: From Biology to Therapy
por: Aikawa, Masanori, et al.
Publicado: (2019)

Mechanosignals in abdominal aortic aneurysms
por: Lowis, Christiana, et al.
Publicado: (2023)

Induced pluripotent stem cell-derived smooth muscle cells to study cardiovascular calcification
por: Atkins, Samantha K., et al.
Publicado: (2022)

Editorial: Extracellular vesicles in cardiovascular inflammation and calcification
por: Krohn, Jona B., et al.
Publicado: (2022)

Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development
por: Decano, Julius L., et al.
Publicado: (2021)

Editorial: Frontiers in Cardiovascular Medicine: Rising Stars 2021
por: Wang, Lijun, et al.
Publicado: (2022)

Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos
por: Singh, Sasha A., et al.
Publicado: (2021)

The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
por: Fehr, Anthony R., et al.
Publicado: (2020)

After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology
por: Hutcheson, Joshua D., et al.
Publicado: (2019)

Editorial: Research reproducibility and preventing fraud
por: Uchida, Shizuka, et al.
Publicado: (2022)

Advanced Research of Abdominal Aortic Aneurysms on Metabolism
por: Hou, Yangfeng, et al.
Publicado: (2021)

Applications of Extracellular Vesicles in Abdominal Aortic Aneurysm
por: Lu, Shan, et al.
Publicado: (2022)

The gut microbiota in experimental abdominal aortic aneurysm
por: Xiao, Jie, et al.
Publicado: (2023)

Status of diagnosis and therapy of abdominal aortic aneurysms
por: Lin, Jinping, et al.
Publicado: (2023)

Embracing Diversity, Equity, and Inclusion in the Scientific Community—Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization
por: Garelnabi, Mahdi, et al.
Publicado: (2022)

Editorial: Highlights in heart valve disease: 2021
por: Elena, Aikawa
Publicado: (2022)

Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms
por: Katsuki, Shunsuke, et al.
Publicado: (2022)

ApoC-III is a novel inducer of calcification in human aortic valves
por: Schlotter, Florian, et al.
Publicado: (2021)

Progress in murine models of ruptured abdominal aortic aneurysm
por: Yin, Li, et al.
Publicado: (2022)

Cellular senescence and abdominal aortic aneurysm: From pathogenesis to therapeutics
por: Wang, Ding, et al.
Publicado: (2022)

Pharmacologic inhibition by spironolactone attenuates experimental abdominal aortic aneurysms
por: Ladd, Zachary, et al.
Publicado: (2023)

Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors?
por: Picatoste, Belén, et al.
Publicado: (2023)

PARPs and ADP-Ribosylation in Chronic Inflammation: A Focus on Macrophages
por: Santinelli-Pestana, Diego V., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bevchr8aaclojvct6dt6848uej