CRISPR-mediated activation of autism gene Itgb3 restores cortical network excitability via mGluR5 signaling

Many mutations in autism spectrum disorder (ASD) affect a single allele, indicating a key role for gene dosage in ASD susceptibility. Recently, haplo-insufficiency of ITGB3, the gene encoding the extracellular matrix receptor β3 integrin, was associated with ASD. Accordingly, Itgb3 knockout (KO) mic...

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Detalles Bibliográficos
Autores principales: Jaudon, Fanny, Thalhammer, Agnes, Zentilin, Lorena, Cingolani, Lorenzo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382421/
https://www.ncbi.nlm.nih.gov/pubmed/36035754
http://dx.doi.org/10.1016/j.omtn.2022.07.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382421/
https://www.ncbi.nlm.nih.gov/pubmed/36035754
http://dx.doi.org/10.1016/j.omtn.2022.07.013

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