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Optogenetic manipulation of cyclic guanosine monophosphate to probe phosphodiesterase activities in megakaryocytes

Cyclic guanosine monophosphate (cGMP) signalling plays a fundamental role in many cell types, including platelets. cGMP has been implicated in platelet formation, but mechanistic detail about its spatio-temporal regulation in megakaryocytes (MKs) is lacking. Optogenetics is a technique which allows...

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Detalles Bibliográficos
Autores principales:	Zhang, Yujing, Benz, Pascal, Stehle, Daniel, Yang, Shang, Kurz, Hendrikje, Feil, Susanne, Nagel, Georg, Feil, Robert, Gao, Shiqiang, Bender, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2022
Materias:	Short Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382455/ https://www.ncbi.nlm.nih.gov/pubmed/35975649 http://dx.doi.org/10.1098/rsob.220058

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