Structural basis of receptor usage by the engineered capsid AAV-PHP.eB

Adeno-associated virus serotype 9 (AAV9) is a promising gene therapy vector for treating neurodegenerative diseases due to its ability to penetrate the blood-brain barrier. PHP.eB was engineered from AAV9 by insertion of a 7-amino acid peptide and point mutation of neighboring residues, thereby enha...

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Detalles Bibliográficos
Autores principales: Jang, Seongmin, Shen, Hao K., Ding, Xiaozhe, Miles, Timothy F., Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382559/
https://www.ncbi.nlm.nih.gov/pubmed/36034770
http://dx.doi.org/10.1016/j.omtm.2022.07.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9382559/
https://www.ncbi.nlm.nih.gov/pubmed/36034770
http://dx.doi.org/10.1016/j.omtm.2022.07.011

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