Tuning through-space interactions via the secondary coordination sphere of an artificial metalloenzyme leads to enhanced Rh(iii)-catalysis

We report computationally-guided protein engineering of monomeric streptavidin Rh(iii) artificial metalloenzyme to enhance catalysis of the enantioselective coupling of acrylamide hydroxamate esters and styrenes. Increased TON correlates with calculated distances between the Rh(iii) metal and surrou...

Descripción completa

Detalles Bibliográficos
Autores principales: Hassan, Isra S., Fuller, Jack T., Dippon, Vanessa N., Ta, Angeline N., Danneman, Michael W., McNaughton, Brian R., Alexandrova, Anastassia N., Rovis, Tomislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384688/
https://www.ncbi.nlm.nih.gov/pubmed/36093000
http://dx.doi.org/10.1039/d2sc03674f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384688/
https://www.ncbi.nlm.nih.gov/pubmed/36093000
http://dx.doi.org/10.1039/d2sc03674f

Ejemplares similares