Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking

Targeting the colchicine binding site of α/β tubulin microtubules can lead to suppression of microtubule dynamics, cell cycle arrest and apoptosis. Therefore, the development of microtubule (MT) inhibitors is considered a promising route to anticancer agents. Our approach to identify novel scaffolds...

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Detalles Bibliográficos
Autores principales: Elseginy, Samia A., Oliveira, A. Sofia F., Shoemark, Deborah K., Sessions, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384815/
https://www.ncbi.nlm.nih.gov/pubmed/36092142
http://dx.doi.org/10.1039/d1md00392e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384815/
https://www.ncbi.nlm.nih.gov/pubmed/36092142
http://dx.doi.org/10.1039/d1md00392e

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