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Working correlates of protection predict SchuS4-derived-vaccine candidates with improved efficacy against an intracellular bacterium, Francisella tularensis

Francisella tularensis, the causative agent of tularemia, is classified as Tier 1 Select Agent with bioterrorism potential. The efficacy of the only available vaccine, LVS, is uncertain and it is not licensed in the U.S. Previously, by using an approach generally applicable to intracellular pathogen...

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Detalles Bibliográficos
Autores principales: De Pascalis, Roberto, Frey, Blake, Rice, Helen M., Bhargava, Varunika, Wu, Terry H., Peterson, Ross L., Conlan, J. Wayne, Sjöstedt, Anders, Elkins, Karen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385090/
https://www.ncbi.nlm.nih.gov/pubmed/35977964
http://dx.doi.org/10.1038/s41541-022-00506-9