A synthetic biology approach reveals diverse and dynamic CDK response profiles via multisite phosphorylation of NLS-NES modules

The complexity of multisite phosphorylation mechanisms in regulating nuclear localization signals (NLSs) and nuclear export signals (NESs) is not understood, and its potential has not been used in synthetic biology. The nucleocytoplasmic shuttling of many proteins is regulated by cyclin-dependent ki...

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Detalles Bibliográficos
Autores principales: Faustova, Ilona, Örd, Mihkel, Kiselev, Viacheslav, Fedorenko, Dmytro, Borovko, Irina, Macs, Dags, Pääbo, Kaur, Lõoke, Marko, Loog, Mart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385143/
https://www.ncbi.nlm.nih.gov/pubmed/35977012
http://dx.doi.org/10.1126/sciadv.abp8992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385143/
https://www.ncbi.nlm.nih.gov/pubmed/35977012
http://dx.doi.org/10.1126/sciadv.abp8992

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