Distinct impact of IgG subclass on autoantibody pathogenicity in different IgG4-mediated diseases

IgG4 is the least potent human IgG subclass for the FcγR-mediated antibody effector function. Paradoxically, IgG4 is also the dominant IgG subclass of pathogenic autoantibodies in IgG4-mediated diseases. Here, we show that the IgG subclass and Fc-FcγR interaction have a distinct impact on the pathog...

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Detalles Bibliográficos
Autores principales: Bi, Yanxia, Su, Jian, Zhou, Shengru, Zhao, Yingjie, Zhang, Yan, Zhang, Huihui, Liu, Mingdong, Zhou, Aiwu, Xu, Jianrong, Pan, Meng, Zhao, Yiming, Li, Fubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385207/
https://www.ncbi.nlm.nih.gov/pubmed/35920621
http://dx.doi.org/10.7554/eLife.76223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385207/
https://www.ncbi.nlm.nih.gov/pubmed/35920621
http://dx.doi.org/10.7554/eLife.76223

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