From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease
Coronary heart disease (CHD) is closely related to oxidative stress and inflammatory response and is the most common cardiovascular disease (CVD). Iron is an essential mineral that participates in many physiological and biochemical reactions in the human body. Meanwhile, on the negative side, iron h...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385341/ https://www.ncbi.nlm.nih.gov/pubmed/35993022 http://dx.doi.org/10.1155/2022/6291889 |
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author | Fan, Xinbiao Li, Aolin Yan, Zhipeng Geng, Xiaofei Lian, Lu Lv, Hao Gao, Dongjie Zhang, Junping |
author_facet | Fan, Xinbiao Li, Aolin Yan, Zhipeng Geng, Xiaofei Lian, Lu Lv, Hao Gao, Dongjie Zhang, Junping |
author_sort | Fan, Xinbiao |
collection | PubMed |
description | Coronary heart disease (CHD) is closely related to oxidative stress and inflammatory response and is the most common cardiovascular disease (CVD). Iron is an essential mineral that participates in many physiological and biochemical reactions in the human body. Meanwhile, on the negative side, iron has an active redox capacity, which leads to the accumulation of reactive oxygen species (ROS) and lipid peroxidation. There is growing evidence that disordered iron metabolism is involved in CHD's pathological progression. And the result of disordered iron metabolism is associated with iron overload-induced programmed cell death, often called ferroptosis. That features iron-dependent lipid peroxidation. Ferroptosis may play a crucial role in the development of CHD, and targeting ferroptosis may be a promising option for treating CHD. Here, we review the mechanisms of iron metabolism in cardiomyocytes (CMs) and explain the correlation between iron metabolism and ferroptosis. Meanwhile, we highlight the specific roles of iron metabolism and ferroptosis in the main pathological progression of CHD. |
format | Online Article Text |
id | pubmed-9385341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-93853412022-08-18 From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease Fan, Xinbiao Li, Aolin Yan, Zhipeng Geng, Xiaofei Lian, Lu Lv, Hao Gao, Dongjie Zhang, Junping Oxid Med Cell Longev Review Article Coronary heart disease (CHD) is closely related to oxidative stress and inflammatory response and is the most common cardiovascular disease (CVD). Iron is an essential mineral that participates in many physiological and biochemical reactions in the human body. Meanwhile, on the negative side, iron has an active redox capacity, which leads to the accumulation of reactive oxygen species (ROS) and lipid peroxidation. There is growing evidence that disordered iron metabolism is involved in CHD's pathological progression. And the result of disordered iron metabolism is associated with iron overload-induced programmed cell death, often called ferroptosis. That features iron-dependent lipid peroxidation. Ferroptosis may play a crucial role in the development of CHD, and targeting ferroptosis may be a promising option for treating CHD. Here, we review the mechanisms of iron metabolism in cardiomyocytes (CMs) and explain the correlation between iron metabolism and ferroptosis. Meanwhile, we highlight the specific roles of iron metabolism and ferroptosis in the main pathological progression of CHD. Hindawi 2022-08-10 /pmc/articles/PMC9385341/ /pubmed/35993022 http://dx.doi.org/10.1155/2022/6291889 Text en Copyright © 2022 Xinbiao Fan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fan, Xinbiao Li, Aolin Yan, Zhipeng Geng, Xiaofei Lian, Lu Lv, Hao Gao, Dongjie Zhang, Junping From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease |
title | From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease |
title_full | From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease |
title_fullStr | From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease |
title_full_unstemmed | From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease |
title_short | From Iron Metabolism to Ferroptosis: Pathologic Changes in Coronary Heart Disease |
title_sort | from iron metabolism to ferroptosis: pathologic changes in coronary heart disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385341/ https://www.ncbi.nlm.nih.gov/pubmed/35993022 http://dx.doi.org/10.1155/2022/6291889 |
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