Identifying mutant-specific multi-drug combinations using comparative network reconstruction

Targeted inhibition of aberrant signaling is an important treatment strategy in cancer, but responses are often short-lived. Multi-drug combinations have the potential to mitigate this, but to avoid toxicity such combinations must be selective and given at low dosages. Here, we present a pipeline to...

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Detalles Bibliográficos
Autores principales: Bosdriesz, Evert, Fernandes Neto, João M., Sieber, Anja, Bernards, René, Blüthgen, Nils, Wessels, Lodewyk F.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385552/
https://www.ncbi.nlm.nih.gov/pubmed/35992065
http://dx.doi.org/10.1016/j.isci.2022.104760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385552/
https://www.ncbi.nlm.nih.gov/pubmed/35992065
http://dx.doi.org/10.1016/j.isci.2022.104760

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