Structural Insights into Porphyrin Recognition by the Human ATP-Binding Cassette Transporter ABCB6

Human ABCB6 is an ATP-binding cassette transporter that regulates heme biosynthesis by translocating various porphyrins from the cytoplasm into the mitochondria. Here we report the cryo-electron microscopy (cryo-EM) structures of human ABCB6 with its substrates, coproporphyrin III (CPIII) and hemin,...

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Detalles Bibliográficos
Autores principales: Kim, Songwon, Lee, Sang Soo, Park, Jun Gyou, Kim, Ji Won, Ju, Seulgi, Choi, Seung Hun, Kim, Subin, Kim, Na Jin, Hong, Semi, Kang, Jin Young, Jin, Mi Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385563/
https://www.ncbi.nlm.nih.gov/pubmed/35950458
http://dx.doi.org/10.14348/molcells.2022.0040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385563/
https://www.ncbi.nlm.nih.gov/pubmed/35950458
http://dx.doi.org/10.14348/molcells.2022.0040

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