Cargando…

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Cardiovascular diseases are the leading cause of premature death and disability worldwide, with both genetic and environmental determinants. While genome-wide association studies have identified multiple genetic loci associated with cardiovascular diseases, exact genes driving these associations rem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ruotsalainen, Sanni E., Surakka, Ida, Mars, Nina, Karjalainen, Juha, Kurki, Mitja, Kanai, Masahiro, Krebs, Kristi, Graham, Sarah, Mishra, Pashupati P., Mishra, Binisha H., Sinisalo, Juha, Palta, Priit, Lehtimäki, Terho, Raitakari, Olli, Milani, Lili, Okada, Yukinori, Palotie, Aarno, Widen, Elisabeth, Daly, Mark J., Ripatti, Samuli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385630/ https://www.ncbi.nlm.nih.gov/pubmed/35978133 http://dx.doi.org/10.1038/s42003-022-03552-0

Ejemplares similares

Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population
por: Helkkula, Pyry, et al.
Publicado: (2023)

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation
por: Saarentaus, Elmo C., et al.
Publicado: (2023)

Polygenic Hyperlipidemias and Coronary Artery Disease Risk
por: Ripatti, Pietari, et al.
Publicado: (2020)

Gene Set Based Integrated Methylome and Transcriptome Analysis Reveals Potential Molecular Mechanisms Linking Cigarette Smoking and Related Diseases
por: Mishra, Pashupati P., et al.
Publicado: (2023)

High-resolution population-specific recombination rates and their effect on phasing and genotype imputation
por: Hassan, Shabbeer, et al.
Publicado: (2020)

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease
por: Helkkula, Pyry, et al.
Publicado: (2021)

The role of polygenic risk and susceptibility genes in breast cancer over the course of life
por: Mars, Nina, et al.
Publicado: (2020)

Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods
por: Lehtimäki, Miikael, et al.
Publicado: (2023)

Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values
por: Drouard, Gabin, et al.
Publicado: (2022)

Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
por: Kiiskinen, Tuomo, et al.
Publicado: (2023)

Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study
por: Mishra, Pashupati P., et al.
Publicado: (2020)

From genetic discovery to future personalized health research
por: Palotie, Aarno, et al.
Publicado: (2013)

Assessment of plasma ceramides as predictor for subclinical atherosclerosis
por: Mishra, Pashupati P., et al.
Publicado: (2021)

Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure
por: Rämö, Joel T., et al.
Publicado: (2023)

Polygenic burden has broader impact on health, cognition, and socioeconomic outcomes than most rare and high-risk copy number variants
por: Saarentaus, Elmo Christian, et al.
Publicado: (2021)

Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
por: Mishra, Binisha H., et al.
Publicado: (2021)

Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure
por: Gaál, Emília Ilona, et al.
Publicado: (2012)

Genetic architecture of human plasma lipidome and its link to cardiovascular disease
por: Tabassum, Rubina, et al.
Publicado: (2019)

Genetic analyses implicate complex links between adult testosterone levels and health and disease
por: Leinonen, Jaakko T., et al.
Publicado: (2023)

Efficient and accurate frailty model approach for genome-wide survival association analysis in large-scale biobanks
por: Dey, Rounak, et al.
Publicado: (2022)

Sleep apnoea is a risk factor for severe COVID-19
por: Strausz, Satu, et al.
Publicado: (2021)

Systematic comparison of family history and polygenic risk across 24 common diseases
por: Mars, Nina, et al.
Publicado: (2022)

C-reactive protein and temperament: An instrumental variable analysis
por: Clemens, Ari, et al.
Publicado: (2021)

Reproductive history and blood cell DNA methylation later in life: the Young Finns Study
por: Harville, Emily W., et al.
Publicado: (2021)

Phenotype of ASDs Associated With 4p16 Risk Locus and Novel Genome-Wide Associations of ASD Patients in the Finnish Population
por: Muroke, Valtteri, et al.
Publicado: (2023)

Targeted Resequencing of the Pericentromere of Chromosome 2 Linked to Constitutional Delay of Growth and Puberty
por: Cousminer, Diana L., et al.
Publicado: (2015)

Genomic prediction of alcohol-related morbidity and mortality
por: Kiiskinen, Tuomo, et al.
Publicado: (2020)

Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom
por: Chheda, Himanshu, et al.
Publicado: (2017)

Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses
por: Sánez Tähtisalo, Heini, et al.
Publicado: (2020)

Genetics of osteopontin in patients with chronic kidney disease: The German Chronic Kidney Disease study
por: Cheng, Yurong, et al.
Publicado: (2022)

High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography
por: Krämer, Robert M., et al.
Publicado: (2023)

Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel
por: Mitt, Mario, et al.
Publicado: (2017)

Human Prostate Tissue MicroRNAs and Their Predicted Target Pathways Linked to Prostate Cancer Risk Factors
por: Enwald, Max, et al.
Publicado: (2021)

Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation
por: Tukiainen, Taru, et al.
Publicado: (2014)

A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip(®) for Methylome Profiling
por: Clark, Christine, et al.
Publicado: (2012)

Increased tooth brushing frequency is associated with reduced gingival pocket bacterial diversity in patients with intracranial aneurysms
por: Pyysalo, Mikko J., et al.
Publicado: (2019)

Similarity of salivary microbiome in parents and adult children
por: Sundström, Kati, et al.
Publicado: (2020)

Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy
por: Tyrmi, Jaakko S., et al.
Publicado: (2023)

Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers
por: Palomäki, Antti, et al.
Publicado: (2021)

The relation of severe malocclusion to patients’ mental and behavioral disorders, growth, and speech problems
por: Koskela, Anu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_18ahm2k78qtcc14s31degeigd2