Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly

Mammalian cells can acquire exogenous amino acids through endocytosis and lysosomal catabolism of extracellular proteins. In amino acid-replete environments, nutritional utilization of extracellular proteins is suppressed by the amino acid sensor mechanistic target of rapamycin complex 1 (mTORC1) th...

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Detalles Bibliográficos
Autores principales: Ratto, Edoardo, Chowdhury, S. Roy, Siefert, Nora S., Schneider, Martin, Wittmann, Marten, Helm, Dominic, Palm, Wilhelm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385660/
https://www.ncbi.nlm.nih.gov/pubmed/35977928
http://dx.doi.org/10.1038/s41467-022-32515-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385660/
https://www.ncbi.nlm.nih.gov/pubmed/35977928
http://dx.doi.org/10.1038/s41467-022-32515-6

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