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Experimental exploration of a ribozyme neutral network using evolutionary algorithm and deep learning
A neutral network connects all genotypes with equivalent phenotypes in a fitness landscape and plays an important role in the mutational robustness and evolvability of biomolecules. In contrast to earlier theoretical works, evidence of large neutral networks has been lacking in recent experimental s...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385714/ https://www.ncbi.nlm.nih.gov/pubmed/35977956 http://dx.doi.org/10.1038/s41467-022-32538-z |