Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety

The human vesicular monoamine transporter 1 (VMAT1) harbors unique substitutions (Asn136Thr/Ile) that affect monoamine uptake into synaptic vesicles. These substitutions are absent in all known mammals, suggesting their contributions to distinct aspects of human behavior modulated by monoaminergic t...

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Detalles Bibliográficos
Autores principales: Sato, Daiki X., Inoue, Yukiko U., Kuga, Nahoko, Hattori, Satoko, Nomoto, Kensaku, Morimoto, Yuki, Sala, Giovanni, Hagihara, Hideo, Kikusui, Takefumi, Sasaki, Takuya, Ikegaya, Yuji, Miyakawa, Tsuyoshi, Inoue, Takayoshi, Kawata, Masakado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385864/
https://www.ncbi.nlm.nih.gov/pubmed/35992083
http://dx.doi.org/10.1016/j.isci.2022.104800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385864/
https://www.ncbi.nlm.nih.gov/pubmed/35992083
http://dx.doi.org/10.1016/j.isci.2022.104800

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