Cargando…

What a Difference an Amino Acid Makes: An All-Atom Simulation Study of Nonameric Peptides in Inhibitory HLA-E/NKG2A/CD94 Immune Complexes

MHC class I antigen E (HLA-E), a ligand for the inhibitory NKG2A/CD94 receptor of the immune system, is responsible for evading the immune surveillance in several settings, including senescent cell accumulation and tumor persistence. The formation of this ligand-receptor interaction promotes the inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prašnikar, Eva, Perdih, Andrej, Borišek, Jure
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9385950/ https://www.ncbi.nlm.nih.gov/pubmed/35991867 http://dx.doi.org/10.3389/fphar.2022.925427

Ejemplares similares

Nonameric Peptide Orchestrates Signal Transduction in the Activating HLA-E/NKG2C/CD94 Immune Complex as Revealed by All-Atom Simulations
por: Prašnikar, Eva, et al.
Publicado: (2021)

All-Atom Simulations Reveal a Key Interaction Network in the HLA-E/NKG2A/CD94 Immune Complex Fine-Tuned by the Nonameric Peptide
por: Prašnikar, Eva, et al.
Publicado: (2021)

All-Atom Simulations Reveal the Intricacies of Signal Transduction upon Binding of the HLA-E Ligand to the Transmembrane Inhibitory CD94/NKG2A Receptor
por: Ljubič, Martin, et al.
Publicado: (2023)

Domain sliding of two Staphylococcus aureus N-acetylglucosaminidases enables their substrate-binding prior to its catalysis
por: Pintar, Sara, et al.
Publicado: (2020)

NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain
por: Hò, Gia-Gia T., et al.
Publicado: (2020)

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence
por: Petrie, Emma J., et al.
Publicado: (2008)

NKG2A Complexed with CD94 Defines a Novel Inhibitory Natural Killer Cell Receptor
por: Brooks, Andrew G., et al.
Publicado: (1997)

Discovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureus
por: Borišek, Jure, et al.
Publicado: (2018)

Disclosing the Impact of Carcinogenic SF3b Mutations on Pre-mRNA Recognition Via All-Atom Simulations
por: Borišek, Jure, et al.
Publicado: (2019)

A Signal Peptide Derived from hsp60 Binds HLA-E and Interferes with CD94/NKG2A Recognition
por: Michaëlsson, Jakob, et al.
Publicado: (2002)

The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice
por: Shreeve, Norman, et al.
Publicado: (2021)

Immunogenicity of Two FMDV Nonameric Peptides Encapsulated in Liposomes in Mice and the Protective Efficacy in Guinea Pigs
por: Gao, Feng-Shan, et al.
Publicado: (2013)

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein
por: Kuhlen, Lucas, et al.
Publicado: (2021)

Recognition of the Class Ib Molecule Qa-1(b) by Putative Activating Receptors Cd94/Nkg2c and Cd94/Nkg2e on Mouse Natural Killer Cells
por: Vance, Russell E., et al.
Publicado: (1999)

Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations: Implications for understanding its catalytic cycle
por: Pavlin, Matic, et al.
Publicado: (2023)

High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation
por: Huisman, Brooke D., et al.
Publicado: (2023)

Publisher Correction: High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation
por: Huisman, Brooke D., et al.
Publicado: (2023)

Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae
por: Zhang, Manfeng, et al.
Publicado: (2020)

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis
por: Borrego, Francisco, et al.
Publicado: (1998)

Downregulation of CD94/NKG2A inhibitory receptors on CD8(+ )T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts
por: Zeddou, Mustapha, et al.
Publicado: (2007)

Astragaloside III Enhances Anti-Tumor Response of NK Cells by Elevating NKG2D and IFN-γ
por: Chen, Xingmeng, et al.
Publicado: (2019)

NKG2D and Its Ligands: “One for All, All for One”
por: Zingoni, Alessandra, et al.
Publicado: (2018)

A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells
por: Davis, Zachary B., et al.
Publicado: (2016)

Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8(+) T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia
por: Pump, Wiebke C., et al.
Publicado: (2019)

Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations
por: DeMarco, Kevin R., et al.
Publicado: (2018)

Inhibitory NKG2A(+) and absent activating NKG2C(+) NK cell responses are associated with the development of EBV(+) lymphomas
por: Vietzen, Hannes, et al.
Publicado: (2023)

Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis
por: Cauli, Alberto, et al.
Publicado: (2018)

Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections
por: Romero-Martín, Luis, et al.
Publicado: (2022)

Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases
por: Petrassi, Mike, et al.
Publicado: (2017)

Molecular signature of eutopic endometrium in endometriosis based on the multi-omics integrative synthesis
por: Prašnikar, Erika, et al.
Publicado: (2020)

Investigating the Molecular Mechanism of H3B-8800: A Splicing Modulator Inducing Preferential Lethality in Spliceosome-Mutant Cancers
por: Spinello, Angelo, et al.
Publicado: (2021)

Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population
por: Koomdee, Napatrupron, et al.
Publicado: (2017)

Differential Expression of NK Receptors CD94 and NKG2A by T Cells in Rheumatoid Arthritis Patients in Remission Compared to Active Disease
por: Walsh, Ceara E., et al.
Publicado: (2011)

HLA-targeted sequencing reveals the pathogenic role of HLA-B*15:02/HLA-B*13:01 in albendazole-induced liver failure: a case report and a review of the literature
por: Liao, Jin-Mao, et al.
Publicado: (2023)

Cytotoxicity of CD56(bright) NK Cells towards Autologous Activated CD4(+) T Cells Is Mediated through NKG2D, LFA-1 and TRAIL and Dampened via CD94/NKG2A
por: Nielsen, Natasja, et al.
Publicado: (2012)

Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population
por: Wang, Chuang-Wei, et al.
Publicado: (2022)

High-Density of FcγRIIIA(+) (CD16(+)) Tumor-Associated Neutrophils in Metastases Improves the Therapeutic Response of Cetuximab in Metastatic Colorectal Cancer Patients, Independently of the HLA-E/CD94-NKG2A Axis
por: Denis Musquer, Marie, et al.
Publicado: (2021)

Diagnostic Test Criteria for HLA Genotyping to Prevent Drug Hypersensitivity Reactions: A Systematic Review of Actionable HLA Recommendations in CPIC and DPWG Guidelines
por: Manson, Lisanne E. N., et al.
Publicado: (2020)

Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A
por: Sarkar, Subhashis, et al.
Publicado: (2015)

Analysis of Qa-1(b)Peptide Binding Specificity and the Capacity of Cd94/Nkg2a to Discriminate between Qa-1–Peptide Complexes
por: Kraft, Jennifer R., et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_jj36op0j0teu2cgs20oae3te5q