Intratumoral electroporation of a self-amplifying RNA expressing IL-12 induces antitumor effects in mouse models of cancer

Alphavirus vectors based on self-amplifying RNA (saRNA) generate high and transient levels of transgene expression and induce innate immune responses, making them an interesting tool for antitumor therapy. These vectors are usually delivered as viral particles, but it is also possible to administer...

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Detalles Bibliográficos
Autores principales: Silva-Pilipich, Noelia, Lasarte-Cía, Aritz, Lozano, Teresa, Martín-Otal, Celia, Lasarte, Juan José, Smerdou, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386029/
https://www.ncbi.nlm.nih.gov/pubmed/36035753
http://dx.doi.org/10.1016/j.omtn.2022.07.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386029/
https://www.ncbi.nlm.nih.gov/pubmed/36035753
http://dx.doi.org/10.1016/j.omtn.2022.07.020

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