IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells

IL11 initiates fibroblast activation but also causes epithelial cell dysfunction. The mechanisms underlying these processes are not known. We report that IL11-stimulated ERK/P90RSK activity causes the phosphorylation of LKB1 at S325 and S428, leading to its inactivation. This inhibits AMPK and activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Widjaja, Anissa A., Viswanathan, Sivakumar, Wei Ting, Joyce Goh, Tan, Jessie, Shekeran, Shamini G., Carling, David, Lim, Wei-Wen, Cook, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386112/
https://www.ncbi.nlm.nih.gov/pubmed/35992082
http://dx.doi.org/10.1016/j.isci.2022.104806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386112/
https://www.ncbi.nlm.nih.gov/pubmed/35992082
http://dx.doi.org/10.1016/j.isci.2022.104806

Ejemplares similares