AAV8BP2 and AAV8 transduce the mammalian cochlear lateral wall and endolymphatic sac with high efficiency

Inner ear gene therapy using adeno-associated viruses (AAVs) has been successfully applied to several mouse models of hereditary hearing loss to improve their auditory function. While most inner ear gene therapy studies have focused on the mechanosensory hair cells and supporting cells in the organ...

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Detalles Bibliográficos
Autores principales: Isgrig, Kevin, Ishibashi, Yasuko, Lee, Hyun Jae, Zhu, Jianliang, Grati, Mhamed, Bennett, Jean, Griffith, Andrew J., Roux, Isabelle, Chien, Wade W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386391/
https://www.ncbi.nlm.nih.gov/pubmed/36034771
http://dx.doi.org/10.1016/j.omtm.2022.07.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386391/
https://www.ncbi.nlm.nih.gov/pubmed/36034771
http://dx.doi.org/10.1016/j.omtm.2022.07.013

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