Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial

BACKGROUND: Impaired double strand DNA repair by homologous repair deficiency (HRD) leads to sensitivity to poly ADP ribose polymerase (PARP) inhibition. Poly-ADP ribose polymerase (PARP) inhibitors target HRD to induce synthetic lethality and are used routinely in the treatment of BRCA1 mutated ova...

Descripción completa

Detalles Bibliográficos
Autores principales: Fennell, Dean A., Porter, Catharine, Lester, Jason, Danson, Sarah, Blackhall, Fiona, Nicolson, Marianne, Nixon, Lisette, Gardner, Georgina, White, Ann, Griffiths, Gareth, Casbard, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386392/
https://www.ncbi.nlm.nih.gov/pubmed/35990583
http://dx.doi.org/10.1016/j.eclinm.2022.101595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386392/
https://www.ncbi.nlm.nih.gov/pubmed/35990583
http://dx.doi.org/10.1016/j.eclinm.2022.101595

Ejemplares similares