Inhibition of NEDD8 NEDDylation induced apoptosis in acute myeloid leukemia cells via p53 signaling pathway

MLN4924 is a potent and selective small-molecule inhibitor of NEDD8-activating enzyme, which showed antitumor effect in several types of malignant tumor types. However, the mechanism of action of MLN4924 in acute myeloid leukemia (AML) requires further investigation. Real-time fluorescent quantitati...

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Detalles Bibliográficos
Autores principales: Chen, Yanli, Sun, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386570/
https://www.ncbi.nlm.nih.gov/pubmed/35880551
http://dx.doi.org/10.1042/BSR20220994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386570/
https://www.ncbi.nlm.nih.gov/pubmed/35880551
http://dx.doi.org/10.1042/BSR20220994

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